Expression of p57kip2, Rb protein and PCNA and their relationships with clinicopathology in human pancreatic cancer

To investigate the effects of inhibiting factor of cell cycle regulation p57(kip2), retinoblastinoma protein (Rb protein) and proliferating cell nuclear antigen (PCNA) in the genesis and progression of human pancreatic cancer. The expression of p57(kip2), Rb protein and PCNA in tumor tissues and adj...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2003-02, Vol.9 (2), p.377-380
Hauptverfasser:	Yue, Hui, Na, Yan-Li, Feng, Xin-Li, Ma, Shu-Ren, Song, Fu-Lin, Yang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Clinical Research Cyclin-Dependent Kinase Inhibitor p57 Female Humans Male Middle Aged Nuclear Proteins - metabolism Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Proliferating Cell Nuclear Antigen - metabolism Retinoblastoma Protein - metabolism
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Zusammenfassung:	To investigate the effects of inhibiting factor of cell cycle regulation p57(kip2), retinoblastinoma protein (Rb protein) and proliferating cell nuclear antigen (PCNA) in the genesis and progression of human pancreatic cancer. The expression of p57(kip2), Rb protein and PCNA in tumor tissues and adjacent tissues of 32 patients with pancreatic cancer was detected with SP immunohistochemical technique. p57(kip2) protein positive-expression rate in tumor tissues of pancreatic cancer was 46.9 %, which was lower than that in adjacent pancreatic tissues (75.0 %) (chi(2)=5.317, P
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v9.i2.377