Mad2 and p27 expression profiles in colorectal cancer and its clinical significance

To investigate the expression of tumor suppressor gene p27 and spindle checkpoint gene Mad2 and to demonstrate their expression difference in colorectal cancer and normal mucosa and to evaluate its clinical significance. Immunohistochemical staining was used for detection of expression of Mad2 and p...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2004-11, Vol.10 (21), p.3218-3220
Hauptverfasser:	Li, Gang-Qiang, Zhang, Hong-Fu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - physiopathology Adult Aged Biomarkers, Tumor Brief Reports Calcium-Binding Proteins - genetics Cell Cycle Proteins - genetics Cell Differentiation Colorectal Neoplasms - metabolism Colorectal Neoplasms - physiopathology Cyclin-Dependent Kinase Inhibitor p27 Female Gene Expression Regulation, Neoplastic Humans Lymphatic Metastasis Mad2 Proteins Male Middle Aged Prognosis Repressor Proteins Tumor Suppressor Proteins - genetics
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Beschreibung
Zusammenfassung:	To investigate the expression of tumor suppressor gene p27 and spindle checkpoint gene Mad2 and to demonstrate their expression difference in colorectal cancer and normal mucosa and to evaluate its clinical significance. Immunohistochemical staining was used for detection of expression of Mad2 and p27 in colorectal cancer and its corresponding normal mucosa. Mad2 was significantly overexpressed in colorectal cancer compared with corresponding normal mucosa (P
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v10.i21.3218