Collectin liver 1 and collectin kidney 1 and other complement‐associated pattern recognition molecules in systemic lupus erythematosus

Summary The objective of this study was to explore the involvement of collectin liver 1 (CL‐L1) and collectin kidney 1 (CL‐K1) and other pattern recognition molecules (PRMs) of the lectin pathway of the complement system in a cross‐sectional cohort of systemic lupus erythematosus (SLE) patients. Concentrations in plasma of CL‐L1, CL‐K1, mannan‐binding lectin (MBL), M‐ficolin, H‐ficolin and L‐ficolin were determined in 58 patients with SLE and 65 healthy controls using time‐resolved immunoflourometric assays. The SLE patients' demographic, diagnostic, clinical and biochemical data and collection of plasma samples were performed prospectively during 4 months. CL‐L1, CL‐K1 and M‐ficolin plasma concentrations were lower in SLE patients than healthy controls (P‐values