Repetitive acute intermittent hypoxia does not promote generalized inflammatory gene expression in the rat CNS

Highlights • rAIH (ten, 5-min hypoxic episodes, thrice weekly, 4 weeks) promotes neuroplasticity. • rAIH at this time does not promote generalized neuroinflammation. • rAIH also does not appear to promote generalized systemic inflammation. • Unlike CIH, rAIH may be a safer option to enhance motor ne...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2015-11, Vol.218, p.1-10
Hauptverfasser:	Peters, Megan E, Kimyon, Rebecca S, Mitchell, Gordon S, Watters, Jyoti J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Stem - immunology Cervical Vertebrae Frontal Lobe - immunology Gene Expression - immunology Hypoxia - immunology Male Medical Education Microglia - immunology Nerve Growth Factors - metabolism Neuroimmunomodulation - physiology Neuronal Plasticity - physiology Pulmonary/Respiratory Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction RNA, Messenger - metabolism Spinal Cord - immunology Spleen - immunology
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Zusammenfassung:	Highlights • rAIH (ten, 5-min hypoxic episodes, thrice weekly, 4 weeks) promotes neuroplasticity. • rAIH at this time does not promote generalized neuroinflammation. • rAIH also does not appear to promote generalized systemic inflammation. • Unlike CIH, rAIH may be a safer option to enhance motor neuron function. • Additional studies with longer term rAIH treatments remain necessary.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2015.07.008