Overactive bladder in adults with sickle cell disease

Aims To characterize the prevalence and impact of nocturnal enuresis and overactive bladder (OAB) symptomatology in the adult sickle‐cell disease (SCD) population. Methods We performed a single‐center, cross‐sectional study of adult SCD patients from October 2012 to February 2014, using the validated Pfizer OAB short form questionnaire and brief voiding history surveys. Patient responses and scores were compared to that of controls having normal or sickle cell trait hemoglobin genotypes. Results A group of 239 SCD patients (116 males, 123 females) were compared with 104 normal and 57 sickle cell trait patients. Seven of 239 (2.9%) SCD patients compared to none of the 161 patients without SCD (P = 0.04) reported current nocturnal enuresis. The median age of nocturnal enuresis cessation was higher in SCD patients (12.0, IQR 9.0–15.0 years) compared to that of both normal (7.5, IQR 6.0–9.8 years) and sickle cell trait (7.5, IQR 6.0–8.8 years) groups (P