Neuroinflammation in Alzheimer’s disease; A source of heterogeneity and target for personalized therapy

Highlights • Microglial heterogeneity is discussed in relation to Alzheimer’s disease and potential functions in the disease. • The potential beneficial and detrimental roles of inflammation in Alzheimer’s disease are discussed. • Introduction of the concept of an inflammatory spectrum to better characterize neuroinflammatory states in disease. • A discussion of the role of neuroinflammatory heterogeneity in the treatment and prevention of Alzheimer’s disease.