A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions

A high-transparency, micro-patternable chip for X-ray diffraction analysis of microcrystals under native growth conditions

Microcrystals present a significant impediment to the determination of macromolecular structures by X‐ray diffraction methods. Although microfocus synchrotron beamlines and X‐ray free‐electron lasers (XFELs) can enable the collection of interpretable diffraction data from microcrystals, there is a n...

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Veröffentlicht in:Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2015-10, Vol.71 (10), p.1987-1997
Hauptverfasser: Murray, Thomas D., Lyubimov, Artem Y., Ogata, Craig M., Vo, Huy, Uervirojnangkoorn, Monarin, Brunger, Axel T., Berger, James M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chickens
Chips
CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY
Crystallization - instrumentation
Crystallography, X-Ray - instrumentation
Devices
Diffraction
Equipment Design
Format
Hydrophobic and Hydrophilic Interactions
Light
Microcrystals
microfluidics
microfocus beamline
Muramidase - chemistry
Particle physics
Research Papers
Scattering
serial data collection
Silicon Compounds - chemistry
silicon nitride
X-ray crystallography
X-rays
XFEL
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Zusammenfassung:Microcrystals present a significant impediment to the determination of macromolecular structures by X‐ray diffraction methods. Although microfocus synchrotron beamlines and X‐ray free‐electron lasers (XFELs) can enable the collection of interpretable diffraction data from microcrystals, there is a need for efficient methods of harvesting small volumes (
ISSN:1399-0047
0907-4449
1399-0047
DOI:10.1107/S1399004715015011