Utility of serum free light chain measurements in multiple myeloma patients not achieving complete response to therapy

Utility of serum free light chain measurements in multiple myeloma patients not achieving complete response to therapy

Normalization of the serum-free light-chain ratio (FLCr) with the absence of bone marrow monoclonal plasma cells following achievement of a complete response (CR) to therapy denotes a stringent CR in multiple myeloma (MM), and is associated with improved overall survival (OS). However, its value in...

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Veröffentlicht in:Leukemia 2015-10, Vol.29 (10), p.2033-2038
Hauptverfasser: Alhaj Moustafa, M, Rajkumar, S V, Dispenzieri, A, Gertz, M A, Lacy, M Q, Buadi, F K, Hwa, Y L, Dingli, D, Kapoor, P, Hayman, S R, Lust, J A, Kyle, R A, Kumar, S K
Format: Artikel
Sprache:eng
Schlagworte:
631/67/1990/804
692/699/1541/1990/804
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Bone marrow
Cancer Research
Chains
Critical Care Medicine
Development and progression
Female
Follow-Up Studies
Hematology
Humans
Immunoglobulin Light Chains - blood
Immunoglobulins
Intensive
Internal Medicine
Male
Medical prognosis
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Multiple myeloma
Multiple Myeloma - blood
Multiple Myeloma - drug therapy
Multiple Myeloma - mortality
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - mortality
Neoplasm Staging
Oncology
original-article
Plasma cells
Prognosis
Remission Induction
Retrospective Studies
Survival
Survival Rate
Therapy
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Zusammenfassung:Normalization of the serum-free light-chain ratio (FLCr) with the absence of bone marrow monoclonal plasma cells following achievement of a complete response (CR) to therapy denotes a stringent CR in multiple myeloma (MM), and is associated with improved overall survival (OS). However, its value in patients achieving
ISSN:0887-6924
1476-5551
DOI:10.1038/leu.2015.118