Efficacy and HIV drug resistance profile of second-line ART among patients having received long-term first-line regimens in rural China

Antiretroviral therapy has significantly expanded and an increased proportion of patients have switched to second-line regimens in China. We describe the outcomes of second-line therapy among patients having received long-term first-line ART. A prospective follow-up study was conducted in rural area...

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Veröffentlicht in:	Scientific reports 2015-10, Vol.5 (1), p.14823-14823, Article 14823
Hauptverfasser:	Wang, Jing, Wang, Zhe, Liu, Jia, Yue, Yanchao, Yang, Shimei, Huang, Huimin, He, Cui, Liao, Lingjie, Xing, Hui, Ruan, Yuhua, Shao, Yiming
Format:	Artikel
Sprache:	eng
Schlagworte:	45/77 692/308/174 692/699/255/1901 Adult Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology China Drug resistance Drug Resistance, Viral - genetics Female Follow-Up Studies HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV-1 - growth & development Humanities and Social Sciences Humans Lamivudine - therapeutic use Lopinavir - therapeutic use Male Middle Aged multidisciplinary Mutation Prospective Studies Protease inhibitors Ribonucleic acid Ritonavir - therapeutic use RNA RNA, Viral - antagonists & inhibitors RNA, Viral - genetics Rural areas Rural Population Science Tenofovir - therapeutic use Treatment Outcome Viral Load - drug effects
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Zusammenfassung:	Antiretroviral therapy has significantly expanded and an increased proportion of patients have switched to second-line regimens in China. We describe the outcomes of second-line therapy among patients having received long-term first-line ART. A prospective follow-up study was conducted in rural areas in China. We compared the virological, immunological outcomes and genotypic drug resistance (DR) profiles before and after regimen switches. A total of 303 patients were enrolled, 283 (93.4%) were retained at 12 months. Of 90 participants with HIV-RNA ≥ 1000 copies/ml before switch, the proportion of viral load (VL) ≥ 1000 copies/ml at 6 and 12 months was 49.4% and 43.9%, respectively. Of 213 patients with HIV-RNA
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep14823