Genetics ignite focus on microglial inflammation in Alzheimer's disease

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretati...

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Veröffentlicht in:	Molecular neurodegeneration 2015-10, Vol.10 (1), p.52-52, Article 52
Hauptverfasser:	Malik, Manasi, Parikh, Ishita, Vasquez, Jared B, Smith, Conor, Tai, Leon, Bu, Guojun, LaDu, Mary Jo, Fardo, David W, Rebeck, G William, Estus, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Analysis Animals Apolipoproteins Genetic aspects Genetic Predisposition to Disease Genetics Humans Inflammation Inflammation - genetics Medical research Medicine, Experimental Microglia - pathology Physiological aspects Polymorphism, Single Nucleotide - genetics Review Risk Factors
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Beschreibung
Zusammenfassung:	In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.
ISSN:	1750-1326 1750-1326
DOI:	10.1186/s13024-015-0048-1