Immunogenicity and efficacy of chimeric dengue vaccine (DENVax) formulations in interferon-deficient AG129 mice

Highlights ► We examine the immunogenicity and efficacy of a chimeric live attenuated dengue vaccine in mice. ► We determine the importance of vaccine formulation and ratios in the immunogenicity of chimeric dengue vaccine in mice. ► We examine the cross protection provided by monovalent dengue vacc...

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Veröffentlicht in:	Vaccine 2012-02, Vol.30 (8), p.1513-1520
Hauptverfasser:	Brewoo, Joseph N, Kinney, Richard M, Powell, Tim D, Arguello, John J, Silengo, Shawn J, Partidos, Charalambos D, Huang, Claire Y.-H, Stinchcomb, Dan T, Osorio, Jorge E
Format:	Artikel
Sprache:	eng
Schlagworte:	AG129 mice Allergy and Immunology Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Body Temperature Body Weight Cell culture chimerism Clinical trials Cloning cross reaction Dengue Dengue - mortality Dengue - pathology Dengue - prevention & control Dengue 2 PDK-53 chimeras Dengue fever Dengue vaccines Dengue Vaccines - administration & dosage Dengue Vaccines - adverse effects Dengue Vaccines - immunology DENVax Disease Disease Models, Animal genes Genomes Good Manufacturing Practice Immune system Immunogenicity Infections interferons Interferons - deficiency Mice Mice, Knockout neutralizing antibodies New Guinea serotypes Studies Survival Analysis Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology Vector-borne diseases Viral Load viremia Viremia - prevention & control Viruses
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Beschreibung
Zusammenfassung:	Highlights ► We examine the immunogenicity and efficacy of a chimeric live attenuated dengue vaccine in mice. ► We determine the importance of vaccine formulation and ratios in the immunogenicity of chimeric dengue vaccine in mice. ► We examine the cross protection provided by monovalent dengue vaccines against lethal viral challenge in mice.
ISSN:	0264-410X 1873-2518 1873-2518
DOI:	10.1016/j.vaccine.2011.11.072