High rates of unplanned interruptions from HIV care early after antiretroviral therapy initiation in Nigeria

Unplanned care interruption (UCI) challenges effective HIV treatment. We determined the frequency and risk factors for UCI in Nigeria. We conducted a retrospective-cohort study of adults initiating antiretroviral therapy (ART) between January 2009 and December 2011. At censor, patients were defined...

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Veröffentlicht in:	BMC infectious diseases 2015-09, Vol.15 (1), p.397, Article 397
Hauptverfasser:	Ahonkhai, Aimalohi A, Banigbe, Bolanle, Adeola, Juliet, Onwuatuelo, Ifeyinwa, Bassett, Ingrid V, Losina, Elena, Freedberg, Kenneth A, Okonkwo, Prosper, Regan, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Anti-HIV Agents - therapeutic use CD4 Lymphocyte Count Censorship Cohort Studies Female Health aspects HIV Infections - drug therapy HIV Infections - virology HIV-1 - genetics Humans Male Multivariate Analysis Nigeria Retrospective Studies Risk Factors RNA, Viral - analysis Treatment Outcome Viral Load
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Zusammenfassung:	Unplanned care interruption (UCI) challenges effective HIV treatment. We determined the frequency and risk factors for UCI in Nigeria. We conducted a retrospective-cohort study of adults initiating antiretroviral therapy (ART) between January 2009 and December 2011. At censor, patients were defined as in care, UCI, or inactive. Associations between baseline factors and UCI rates were quantified using Poisson regression. Among 2,496 patients, 44 % remained in care, 35 % had ≥1 UCI, and 21 % became inactive. UCI rates were higher in the first year on ART (39/100PY), than the second (19/100PY), third (16/100PY), and fourth (14/100PY) years (p 350/uL (IRR 3.21, p
ISSN:	1471-2334 1471-2334
DOI:	10.1186/s12879-015-1137-z