Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk

Both the low animal cell density of bioreactors and their ability to post-translationally process recombinant factor IX (rFIX) limit hemophilia B therapy to

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Veröffentlicht in:	Scientific reports 2015-09, Vol.5 (1), p.14176-14176, Article 14176
Hauptverfasser:	Zhao, Jianguo, Xu, Weijie, Ross, Jason W., Walters, Eric M., Butler, Stephen P., Whyte, Jeff J., Kelso, Lindsey, Fatemi, Mostafa, Vanderslice, Nicholas C., Giroux, Keith, Spate, Lee D., Samuel, Melissa S., Murphy, Cliff N., Wells, Kevin D., Masiello, Nick C., Prather, Randall S., Velander, William H.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61 692/699/1541 Animals Animals, Genetically Modified Bioreactors Carboxylation Cell density Coagulation Coagulation factors Factor IX - genetics Factor IX - metabolism Factor IX - therapeutic use Factor IX deficiency Female Furin Furin - genetics Furin - metabolism Golgi apparatus Hemophilia Hemophilia B - therapy Humanities and Social Sciences Humans Lactation Lactation - metabolism Livestock Male Mammary gland Mammary Glands, Animal - metabolism Milk Milk - metabolism multidisciplinary Post-translation Protein engineering Protein Engineering - methods Protein Processing, Post-Translational Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - therapeutic use Science Swine
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Zusammenfassung:	Both the low animal cell density of bioreactors and their ability to post-translationally process recombinant factor IX (rFIX) limit hemophilia B therapy to
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep14176