Down-regulation of microRNA152 is associated with the diagnosis and prognosis of patients with osteosarcoma

Potential values of microRNA152 (miR-152) as a serum diagnostic and prognostic biomarker have not been determined in human osteosarcoma. By detecting the expression of miR-152 among 80 osteosarcoma patients, 20 periostitis patients and 20 healthy individuals using qRT-PCR, we aimed to explore the cl...

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Veröffentlicht in:	International journal of clinical and experimental pathology 2015-01, Vol.8 (8), p.9314-9319
Hauptverfasser:	Wang, Nai-Guo, Wang, Da-Chuan, Tan, Bing-Yi, Wang, Feng, Yuan, Ze-Nong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - mortality Bone Neoplasms - pathology Disease-Free Survival Down-Regulation Female Humans Male MicroRNAs - genetics MicroRNAs - metabolism Original Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - mortality Osteosarcoma - pathology Prognosis Survival Rate Young Adult
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Zusammenfassung:	Potential values of microRNA152 (miR-152) as a serum diagnostic and prognostic biomarker have not been determined in human osteosarcoma. By detecting the expression of miR-152 among 80 osteosarcoma patients, 20 periostitis patients and 20 healthy individuals using qRT-PCR, we aimed to explore the clinical significance of miR-152 in osteosarcoma patients. The expression of miR-152 was significantly decreased in patients with osteosarcoma compared to patients with periostitis (P
ISSN:	1936-2625