Structural Insight into Specificity of Interactions between Nonconventional Three-finger Weak Toxin from Naja kaouthia (WTX) and Muscarinic Acetylcholine Receptors

Weak toxin from Naja kaouthia (WTX) belongs to the group of nonconventional “three-finger” snake neurotoxins. It irreversibly inhibits nicotinic acetylcholine receptors and allosterically interacts with muscarinic acetylcholine receptors (mAChRs). Using site-directed mutagenesis, NMR spectroscopy, a...

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Veröffentlicht in:	The Journal of biological chemistry 2015-09, Vol.290 (39), p.23616-23630
Hauptverfasser:	Lyukmanova, Ekaterina N., Shenkarev, Zakhar O., Shulepko, Mikhail A., Paramonov, Alexander S., Chugunov, Anton O., Janickova, Helena, Dolejsi, Eva, Dolezal, Vladimir, Utkin, Yuri N., Tsetlin, Victor I., Arseniev, Alexander S., Efremov, Roman G., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals computer modeling Elapid Venoms - chemistry Elapidae G protein-coupled receptor (GPCR) Molecular Sequence Data Mutagenesis, Insertional Neurobiology Neurotoxins - chemistry Neurotoxins - genetics Neurotoxins - metabolism nuclear magnetic resonance (NMR) Nuclear Magnetic Resonance, Biomolecular Protein Binding Protein Conformation protein dynamic Receptors, Muscarinic - metabolism recombinant protein expression Sequence Homology, Amino Acid site-directed mutagenesis snake neurotoxin
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