Regulatory SNPs and transcriptional factor binding sites in ADRBK1, AKT3, ATF3, DIO2, TBXA2R and VEGFA

Regulatory single nucleotide polymorphisms (rSNPs) which change the transcriptional factor binding sites (TFBS) for transcriptional factors (TFs) to bind DNA were reviewed for the ADRBK1 (GRK2), AKT3, ATF3, DIO2, TBXA2R and VEGFA genes. Changes in the TFBS where TFs attach to regulate these genes ma...

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Veröffentlicht in:	Transcription 2014-08, Vol.5 (4), p.e964559-e964559
1. Verfasser:	Buroker, Norman E
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - chemistry Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism ADRBK1 AKT3 ATF3 Binding Sites DIO2 G-Protein-Coupled Receptor Kinase 2 - chemistry G-Protein-Coupled Receptor Kinase 2 - genetics G-Protein-Coupled Receptor Kinase 2 - metabolism Genome-Wide Association Study Humans Iodide Peroxidase - chemistry Iodide Peroxidase - genetics Iodide Peroxidase - metabolism Iodothyronine Deiodinase Type II Polymorphism, Single Nucleotide Proto-Oncogene Proteins c-akt - chemistry Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Receptors, Thromboxane A2, Prostaglandin H2 - genetics Review rSNPs TBXA2R and VEGFA genes Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism transcriptional factor binding site transcriptional factors Untranslated Regions Vascular Endothelial Growth Factor A - chemistry Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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Zusammenfassung:	Regulatory single nucleotide polymorphisms (rSNPs) which change the transcriptional factor binding sites (TFBS) for transcriptional factors (TFs) to bind DNA were reviewed for the ADRBK1 (GRK2), AKT3, ATF3, DIO2, TBXA2R and VEGFA genes. Changes in the TFBS where TFs attach to regulate these genes may result in human sickness and disease. The highlights of this previous work were reviewed for these genes.
ISSN:	2154-1264 2154-1272
DOI:	10.4161/21541264.2014.964559