Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy

Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy

Circulating microRNAs may represent novel markers for cardiovascular diseases. We evaluated whether circulating miRNAs served as potential biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM). Cardiac magnetic resonance imaging with postcontrast T1 mapping wa...

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Veröffentlicht in:Journal of translational medicine 2015-09, Vol.13 (1), p.314-314, Article 314
Hauptverfasser: Fang, Lu, Ellims, Andris H, Moore, Xiao-lei, White, David A, Taylor, Andrew J, Chin-Dusting, Jaye, Dart, Anthony M
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Area Under Curve
Biological markers
Biomarkers - blood
Cardiac patients
Cardiomyopathy, Hypertrophic
Cardiomyopathy, Hypertrophic - blood
Cardiovascular diseases
Care and treatment
Case-Control Studies
Cohort Studies
Complications and side effects
Echocardiography
Female
Fibrosis
Glomerular Filtration Rate
Humans
Magnetic Resonance Imaging
Male
MicroRNA
MicroRNAs - blood
MicroRNAs - metabolism
Middle Aged
Myocardium - pathology
Real-Time Polymerase Chain Reaction
Risk factors
RNA - analysis
ROC Curve
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Zusammenfassung:Circulating microRNAs may represent novel markers for cardiovascular diseases. We evaluated whether circulating miRNAs served as potential biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM). Cardiac magnetic resonance imaging with postcontrast T1 mapping was performed to non-invasively quantify diffuse myocardial fibrosis in HCM patients who were classified into two groups (T1 
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-015-0672-0