The IL-33/ST2 axis is specifically required for development of adipose tissue-resident regulatory T cells

Currently, T cells dedicated to medi- ating immunosuppression and homeostasis are called regulatory T （Treg） cells. Treg cells are closely assoc- iated with infection, allergy, autoimmunity, tumor immunity, fetal-maternal tolerance, and organ transplantation. Treg cells exert their immunosuppressive...

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Veröffentlicht in:	Cellular & molecular immunology 2015-09, Vol.12 (5), p.521-524
Hauptverfasser:	Hu, Zhi‐Qing, Zhao, Wei‐Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Animals Antibodies Biomedical and Life Sciences Biomedicine Body fat eg细胞 Humans Immunology Immunoregulation Interleukin-1 Receptor-Like 1 Protein Interleukin-33 - metabolism Intra-Abdominal Fat - cytology Lymphocyte Subsets - immunology Lymphocytes T Medical Microbiology Mice, Inbred C57BL Microbiology Models, Biological Phenotype Receptors, Interleukin - metabolism Research Highlight Signal Transduction T-Lymphocytes, Regulatory - immunology T细胞发育 Vaccine 免疫抑制居民抗原提呈细胞树突状细胞脂肪组织调节性T细胞
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Beschreibung
Zusammenfassung:	Currently, T cells dedicated to medi- ating immunosuppression and homeostasis are called regulatory T （Treg） cells. Treg cells are closely assoc- iated with infection, allergy, autoimmunity, tumor immunity, fetal-maternal tolerance, and organ transplantation. Treg cells exert their immunosuppressive functions by directly killing or inhibiting T cells and antigen-presenting cells （dendritic cells, macrophages,
ISSN:	1672-7681 2042-0226 2042-0226
DOI:	10.1038/cmi.2015.49