FOXP3 ＋ regulatory T cells and their functional regulation

FOXP3＋ regulatory T （Treg） cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings...

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Veröffentlicht in:	Cellular & molecular immunology 2015-09, Vol.12 (5), p.558-565
Hauptverfasser:	Li, Zhiyuan, Li, Dan, Tsun, Andy, Li, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Autoimmune diseases Biomedical and Life Sciences Biomedicine Cell therapy Clinical Trials as Topic Forkhead Transcription Factors - metabolism Foxp3 protein Functional plasticity Graft-versus-host reaction Homeostasis Humans Immune system Immunological tolerance Immunology Immunoregulation Lymphocytes T Medical Microbiology Microbiology Molecular modelling Protein Processing, Post-Translational Review T-Lymphocytes, Regulatory - immunology Vaccine 免疫系统免疫耐受分子机制功能调控潜在用途移植物抗宿主病自身免疫性疾病调节性T细胞
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Beschreibung
Zusammenfassung:	FOXP3＋ regulatory T （Treg） cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease （GVHD） and cancer.
ISSN:	1672-7681 2042-0226
DOI:	10.1038/cmi.2015.10