Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance

To investigate the expression of three types of mucin (MUC1, MUC2, MUC5AC) and E-cadherin in human gastric carcinomas and their clinical significance. Ninety-four gastric cancer specimens were classified according to WHO criteria and detected by immunohistochemical assay of expression of mucins and...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2004-10, Vol.10 (20), p.3044-3047
Hauptverfasser:	Zhang, Hong-Kai, Zhang, Qiu-Min, Zhao, Tie-Hua, Li, Yuan-Yuan, Yi, Yong-Fen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - surgery Adult Aged Biomarkers, Tumor - metabolism Brief Reports Cadherins - metabolism Female Gastrectomy Humans Immunohistochemistry Male Middle Aged Mucin-1 - metabolism Mucin-2 Mucins - metabolism Peptide Fragments - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - surgery
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Zusammenfassung:	To investigate the expression of three types of mucin (MUC1, MUC2, MUC5AC) and E-cadherin in human gastric carcinomas and their clinical significance. Ninety-four gastric cancer specimens were classified according to WHO criteria and detected by immunohistochemical assay of expression of mucins and E-cadherin. The positive expression rates of MUC1, MUC2, MUC5AC and E-cadherin were 82% (77/94), 84% (79/94), 40% (38/94) and 56% (53/94) respectively. MUC1 expression was significantly correlated with the types of cancer (the positive rates of MUC1 in well and moderately differentiated tubular adenocarcinoma, poorly differentiated adenocarcinoma, signet-ring cell carcinoma and mucinous carcinoma were 91%, 87%, 71%, 71%, respectively, P
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v10.i20.3044