Oritavancin Pharmacokinetics and Bone Penetration in Rabbits

Oritavancin Pharmacokinetics and Bone Penetration in Rabbits

The pharmacokinetics and bone concentrations of oritavancin were investigated after a single intravenous dose was administered to rabbits. The pharmacokinetic profile of oritavancin in rabbits showed that it is rapidly distributed to bone tissues, with concentrations remaining stable for up to 168 h...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2015-10, Vol.59 (10), p.6501-6505
Hauptverfasser: Lehoux, Dario, Ostiguy, Valerie, Cadieux, Cordelia, Malouin, Mireille, Belanger, Odette, Far, Adel Rafai, Parr, Jr, Thomas R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anti-Bacterial Agents
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Area Under Curve
Biological Availability
Biological Transport
Bone Marrow
Bone Marrow - chemistry
Bone Marrow - metabolism
Glycopeptides
Glycopeptides - blood
Glycopeptides - pharmacokinetics
Injections, Intravenous
Male
Pharmacology
Rabbits
Tibia
Tibia - chemistry
Tibia - metabolism
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Zusammenfassung:The pharmacokinetics and bone concentrations of oritavancin were investigated after a single intravenous dose was administered to rabbits. The pharmacokinetic profile of oritavancin in rabbits showed that it is rapidly distributed to bone tissues, with concentrations remaining stable for up to 168 h, the last measured time point. Based on these findings, further evaluation of oritavancin for the treatment of infections in bone tissues is warranted.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00981-15