Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant

We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant o...

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Veröffentlicht in:	Journal of clinical microbiology 2015-10, Vol.53 (10), p.3341-3344
Hauptverfasser:	Giani, Tommaso, Arena, Fabio, Vaggelli, Guendalina, Conte, Viola, Chiarelli, Adriana, Henrici De Angelis, Lucia, Fornaini, Rossella, Grazzini, Maddalena, Niccolini, Fabrizio, Pecile, Patrizia, Rossolini, Gian Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacteremia - epidemiology Bacteremia - microbiology Bacterial Proteins - genetics Bacterial Proteins - secretion Bacteriology beta-Lactamases - secretion Colistin - pharmacology Cross Infection - epidemiology Cross Infection - microbiology Disease Outbreaks Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field Genotype Humans Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Molecular Typing Sequence Deletion
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Zusammenfassung:	We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.01017-15