Coordinate increase of telomerase activity and c-Myc expression in Helicobacter pylori-associated gastric diseases

To detect the telomerase activity and c-Myc expression in gastric diseases and to examine the relation between these values and Helicobacter pylori (H pylori) as a risk factor for gastric cancer. One hundred and seventy-one gastric samples were studied to detect telomerase activity using a telomeras...

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Veröffentlicht in:World journal of gastroenterology : WJG 2004-06, Vol.10 (12), p.1759-1762
Hauptverfasser: Zhang, Guo-Xin, Gu, Yan-Hong, Zhao, Zhi-Quan, Xu, Shun-Fu, Zhang, Hong-Ji, Wang, Hong-Di, Hao, Bo
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Sprache:eng
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Zusammenfassung:To detect the telomerase activity and c-Myc expression in gastric diseases and to examine the relation between these values and Helicobacter pylori (H pylori) as a risk factor for gastric cancer. One hundred and seventy-one gastric samples were studied to detect telomerase activity using a telomerase polymerase chain reaction enzyme linked immunosorbent assay (PCR-ELISA), and c-Myc expression using immunohistochemistry. The telomerase activity and c-Myc expression were higher in cancers (87.69% and 61.54%) than in noncancerous tissues. They were higher in chronic atrophic gastritis with severe intestinal metaplasia (52.38% and 47.62%) than in chronic atrophic gastritis with mild intestinal metaplasia (13.33% and 16.67%). In chronic atrophic gastritis with severe intestinal metaplasia, the telomerase activity and c-Myc expression were higher in cases with H pylori infection (67.86% and 67.86%) than in those without infection (21.43% and 7.14%). c-Myc expression was higher in gastric cancer with H pylori infection (77.27%) than in that without infection (28.57%). The telomerase activity and c-Myc expression were coordinately up-regulated in H pylori infected gastric cancer and chronic atrophic gastritis with severe intestinal metaplasia. H pylori infection may influence both telomerase activity and c-Myc expression in gastric diseases, especially in chronic atrophic gastritis.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v10.i12.1759