1H, 15N, 13C resonance assignment of human osteopontin

Osteopontin (OPN) is a 33.7 kDa intrinsically disordered protein and a member of the SIBLING family of proteins. OPN is bearing a signal peptide for secretion into the extracellular space, where it exerts its main physiological function, the control of calcium biomineralization. It is often involved...

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Veröffentlicht in:	Biomolecular NMR assignments 2015, Vol.9 (2), p.289-292
Hauptverfasser:	Platzer, Gerald, Żerko, Szymon, Saxena, Saurabh, Koźmiński, Wiktor, Konrat, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and Medical Physics Biophysics Physics Physics and Astronomy Polymer Sciences
Online-Zugang:	Volltext
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Zusammenfassung:	Osteopontin (OPN) is a 33.7 kDa intrinsically disordered protein and a member of the SIBLING family of proteins. OPN is bearing a signal peptide for secretion into the extracellular space, where it exerts its main physiological function, the control of calcium biomineralization. It is often involved in tumorigenic processes influencing proliferation, migration and survival, as well as the adhesive properties of cancer cells via CD44 and integrin signaling pathways. Here we report the nearly complete NMR chemical shift assignment of recombinant human osteopontin.
ISSN:	1874-2718 1874-270X
DOI:	10.1007/s12104-014-9594-7