Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits

Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological m...

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Veröffentlicht in:	Current diabetes reports 2015-10, Vol.15 (10), p.83-83, Article 83
Hauptverfasser:	Karaderi, Tugce, Drong, Alexander W., Lindgren, Cecilia M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - genetics Animals Diabetes Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Genetic Loci Genetic Predisposition to Disease Genetics (AP Morris Genetics (AP Morris, Section Editor) Genome-Wide Association Study Humans Medicine Medicine & Public Health Obesity - complications Obesity - genetics Section Editor Topical Collection on Genetics
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Beschreibung
Zusammenfassung:	Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.
ISSN:	1534-4827 1539-0829
DOI:	10.1007/s11892-015-0648-8