Association of Chronic Kidney Disease With Chronotropic Incompetence in Heart Failure With Preserved Ejection Fraction

Chronotropic incompetence (CI) is common in heart failure with preserved ejection fraction (HFpEF) and may be a key reason underlying exercise intolerance in these patients. However, the determinants of CI in HFpEF are unknown. We prospectively studied 157 patients with consecutive HFpEF who underwe...

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Veröffentlicht in:	The American journal of cardiology 2015-10, Vol.116 (7), p.1093-1100
Hauptverfasser:	Klein, David A., MS, Katz, Daniel H., MD, Beussink-Nelson, Lauren, MHS, RDCS, Sanchez, Cynthia L., BA, Strzelczyk, Theresa A., APN, CCNS, Shah, Sanjiv J., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Blood pressure Carbon dioxide Cardiology Cardiovascular Diuretics Exercise Exercise Test Exercise Tolerance - physiology Female Follow-Up Studies Fractions Heart failure Heart Failure - complications Heart Failure - physiopathology Heart rate Heart Rate - physiology Humans Illinois - epidemiology Kidney diseases Laboratories Male Middle Aged Mortality Prevalence Prognosis Pulmonary arteries Regression analysis Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - physiopathology Retrospective Studies Stroke Volume - physiology Studies Variables
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Zusammenfassung:	Chronotropic incompetence (CI) is common in heart failure with preserved ejection fraction (HFpEF) and may be a key reason underlying exercise intolerance in these patients. However, the determinants of CI in HFpEF are unknown. We prospectively studied 157 patients with consecutive HFpEF who underwent cardiopulmonary exercise testing and defined CI according to specific thresholds of the percent heart rate reserve (%HRR). CI was diagnosed as present if %HRR
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2015.06.038