General overview on structure prediction of twilight-zone proteins

General overview on structure prediction of twilight-zone proteins

Protein structure prediction from amino acid sequence has been one of the most challenging aspects in computational structural biology despite significant progress in recent years showed by critical assessment of protein structure prediction (CASP) experiments. When experimentally determined structu...

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Veröffentlicht in:Theoretical biology and medical modelling 2015-09, Vol.12 (1), p.15-15, Article 15
Hauptverfasser: Khor, Bee Yin, Tye, Gee Jun, Lim, Theam Soon, Choong, Yee Siew
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Comparative analysis
Computational Biology - methods
Models, Molecular
Molecular Sequence Data
Protein structure prediction
Proteins
Proteins - chemistry
Review
Sequence Analysis, Protein
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Zusammenfassung:Protein structure prediction from amino acid sequence has been one of the most challenging aspects in computational structural biology despite significant progress in recent years showed by critical assessment of protein structure prediction (CASP) experiments. When experimentally determined structures are unavailable, the predictive structures may serve as starting points to study a protein. If the target protein consists of homologous region, high-resolution (typically
ISSN:1742-4682
1742-4682
DOI:10.1186/s12976-015-0014-1