Mechanisms regulating cytochrome c release in pancreatic mitochondria

Background: Mechanisms of acinar cell death in pancreatitis are poorly understood. Cytochrome c release is a central event in apoptosis in pancreatitis. Here, we assessed the regulation of pancreatic cytochrome c release by Ca2+, mitochondrial membrane potential (ΔΨm), and reactive oxygen species (R...

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Veröffentlicht in:	Gut 2009-03, Vol.58 (3), p.431-442
Hauptverfasser:	Odinokova, I V, Sung, K-F, Mareninova, O A, Hermann, K, Evtodienko, Y, Andreyev, A, Gukovsky, I, Gukovskaya, A S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Calcium - metabolism Calcium Signaling Cell Death - physiology Cytochrome Cytochromes c - metabolism Gangrene Membrane Potential, Mitochondrial - physiology Mitochondria Mitochondria - metabolism Mitochondrial DNA Mitochondrial Membrane Transport Proteins - metabolism Pancreas - metabolism Pancreas - physiology Pancreatitis - metabolism Pancreatitis - physiopathology Permeability Rats Reactive Oxygen Species - metabolism Rodents
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