Abdominal Obesity Contributes to Neurocognitive Impairment in HIV-Infected Patients With Increased Inflammation and Immune Activation

Abdominal Obesity Contributes to Neurocognitive Impairment in HIV-Infected Patients With Increased Inflammation and Immune Activation

OBJECTIVE:We tested our hypothesis that abdominal obesity when associated with increased levels of systemic and central nervous system immunoinflammatory mediators contributes to neurocognitive impairment (NCI). DESIGN:Cross-sectional. SETTING:Six Academic Centers. PARTICIPANTS:One hundred fifty-two...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 2015-03, Vol.68 (3), p.281-288
Hauptverfasser: Sattler, Fred R, He, Jiaxiu, Letendre, Scott, Wilson, Cara, Sanders, Chelsea, Heaton, Robert, Ellis, Ronald, Franklin, Donald, Aldrovandi, Grace, Marra, Christina M, Clifford, David, Morgello, Susan, Grant, Igor, McCutchan, J Allen
Format: Artikel
Sprache:eng
Schlagworte:
Abdomen
Adult
Aged
AIDS Dementia Complex - epidemiology
Cohort Studies
Correlation analysis
Cross-Sectional Studies
Cytokines - blood
Female
HIV
HIV Infections - complications
Human immunodeficiency virus
Humans
Immune system
Inflammation - complications
Inflammation - immunology
Male
Middle Aged
Neurological disorders
Obesity
Obesity, Abdominal - complications
Ribonucleic acid
RNA
Young Adult
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Zusammenfassung:OBJECTIVE:We tested our hypothesis that abdominal obesity when associated with increased levels of systemic and central nervous system immunoinflammatory mediators contributes to neurocognitive impairment (NCI). DESIGN:Cross-sectional. SETTING:Six Academic Centers. PARTICIPANTS:One hundred fifty-two patients with plasma HIV RNA
ISSN:1525-4135
1944-7884
DOI:10.1097/QAI.0000000000000458