Molecular biomarkers screened by next-generation RNA sequencing for non-sentinel lymph node status prediction in breast cancer patients with metastatic sentinel lymph nodes

Molecular biomarkers screened by next-generation RNA sequencing for non-sentinel lymph node status prediction in breast cancer patients with metastatic sentinel lymph nodes

Non-sentinel lymph node (NSLN) status prediction with molecular biomarkers may make some sentinel lymph node (SLN) positive breast cancer patients avoid the axillary lymph node dissection, but the available markers remain limited. SLN positive patients with and without NSLN invasion were selected, a...

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Veröffentlicht in:World journal of surgical oncology 2015-08, Vol.13 (1), p.258-258, Article 258
Hauptverfasser: Liang, Feng, Qu, Hongzhu, Lin, Qiang, Yang, Yadong, Ruan, Xiuyan, Zhang, Bo, Liu, Yi, Yu, Chengze, Zhang, Hongyan, Fang, Xiangdong, Hao, Xiaopeng
Format: Artikel
Sprache:eng
Schlagworte:
Biological markers
Biomarkers, Tumor - genetics
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cancer
Cancer patients
Carcinoma, Ductal, Breast - genetics
Carcinoma, Ductal, Breast - secondary
Carcinoma, Ductal, Breast - surgery
Development and progression
Diagnosis
Female
Follow-Up Studies
Genes
Genetic aspects
High-Throughput Nucleotide Sequencing - methods
Humans
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic Metastasis
Metastasis
Neoplasm Grading
Neoplasm Staging
Oncology, Experimental
Physiological aspects
Prognosis
Risk factors
RNA
RNA sequencing
Sentinel Lymph Node Biopsy
Sequence Analysis, RNA - methods
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Zusammenfassung:Non-sentinel lymph node (NSLN) status prediction with molecular biomarkers may make some sentinel lymph node (SLN) positive breast cancer patients avoid the axillary lymph node dissection, but the available markers remain limited. SLN positive patients with and without NSLN invasion were selected, and genes differentially expressed or fused in SLN metastasis were screened by next-generation RNA sequencing. Six candidates (all ER/PR+, HER2-, Ki-67
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-015-0642-2