Chromatin states and nuclear organization in development--a view from the nuclear lamina

The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping...

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Veröffentlicht in:	Genome Biology 2015-08, Vol.16 (1), p.174-174, Article 174
Hauptverfasser:	Mattout, Anna, Cabianca, Daphne S, Gasser, Susan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell cycle Cell Differentiation - genetics Chromatin Chromatin - chemistry Chromatin - metabolism Chromosomes Deoxyribonucleic acid DNA DNA methylation Epigenesis, Genetic Epigenetics Fibroblasts Gene expression Genetic engineering Genome Genomes Genomics Heterochromatin Heterochromatin - metabolism Histones - metabolism Humans interphase Lamins - genetics Mice Mutation nuclear lamina Nuclear Lamina - genetics Physiological aspects Proteins Review Spatial distribution Stem cells
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Zusammenfassung:	The spatial distribution of chromatin domains in interphase nuclei changes dramatically during development in multicellular organisms. A crucial question is whether nuclear organization is a cause or a result of differentiation. Genetic perturbation of lamina-heterochromatin interactions is helping to reveal the cross-talk between chromatin states and nuclear organization.
ISSN:	1474-760X 1474-7596 1474-760X
DOI:	10.1186/s13059-015-0747-5