Maternal preconception body mass index and offspring cord blood DNA methylation: Exploration of early life origins of disease

Maternal preconception body mass index and offspring cord blood DNA methylation: Exploration of early life origins of disease

Maternal obesity is associated with a variety of common diseases in the offspring. One possible underlying mechanism could be maternal obesity induced alterations in DNA methylation. However, this hypothesis is yet to be tested. We performed epigenomic mapping of cord blood among 308 Black mother‐in...

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Veröffentlicht in:Environmental and molecular mutagenesis 2014-04, Vol.55 (3), p.223-230
Hauptverfasser: Liu, Xin, Chen, Qi, Tsai, Hui-Ju, Wang, Guoying, Hong, Xiumei, Zhou, Ying, Zhang, Chunling, Liu, Chunyu, Liu, Rong, Wang, Hongjian, Zhang, Shanchun, Yu, Yunxian, Mestan, Karen K., Pearson, Colleen, Otlans, Peters, Zuckerman, Barry, Wang, Xiaobin
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Blood
Body Mass Index
cord blood
CpG Islands
Deoxyribonucleic acid
DNA
DNA Methylation
early life origins of disease
Epigenesis, Genetic
Female
Fetal Blood - metabolism
Gene Expression Regulation
Genes
Humans
Infant, Newborn
Lipids - chemistry
Male
maternal BMI
Mothers
Neoplasms - genetics
Obesity - genetics
Obesity - metabolism
Oligonucleotide Array Sequence Analysis
Pregnancy
Pregnancy Complications
Quality Control
Regression Analysis
Young Adult
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Beschreibung
Zusammenfassung:Maternal obesity is associated with a variety of common diseases in the offspring. One possible underlying mechanism could be maternal obesity induced alterations in DNA methylation. However, this hypothesis is yet to be tested. We performed epigenomic mapping of cord blood among 308 Black mother‐infant pairs delivered at term at the Boston Medical Center using the Illumina HumanMethylation27 BeadChip. Linear regression and pathway analyses were conducted to evaluate the associations between DNA methylation levels and prepregnancy maternal BMI (
ISSN:0893-6692
1098-2280
DOI:10.1002/em.21827