Liver X receptors at the intersection of lipid metabolism and atherogenesis

Highlights • LXRs are sterol-responsive transcription factors that protect against atherosclerosis. • Activation of LXRs improves reverse cholesterol transport and reduces inflammation. • This review includes newly discovered atheroprotective gene targets of LXRs.

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Bibliographische Detailangaben
Veröffentlicht in:	Atherosclerosis 2015-09, Vol.242 (1), p.29-36
Hauptverfasser:	Lee, Stephen D, Tontonoz, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - pathology ATP Binding Cassette Transporter 1 - metabolism Biological Transport Cardiovascular Cholesterol - metabolism Disease Progression Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enterocytes - metabolism Hepatocytes - metabolism Homeostasis Humans Hypercholesterolemia - complications Hypercholesterolemia - metabolism Inflammation Intestine, Small - metabolism Lipid Metabolism Lipoproteins - metabolism Liver X Receptors LXR Macrophages - metabolism Molecular Targeted Therapy Nuclear receptor Orphan Nuclear Receptors - agonists Orphan Nuclear Receptors - physiology Signal Transduction
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Beschreibung
Zusammenfassung:	Highlights • LXRs are sterol-responsive transcription factors that protect against atherosclerosis. • Activation of LXRs improves reverse cholesterol transport and reduces inflammation. • This review includes newly discovered atheroprotective gene targets of LXRs.
ISSN:	0021-9150 1879-1484
DOI:	10.1016/j.atherosclerosis.2015.06.042