Metabolomics and Natural-Products Strategies to Study Chemical Ecology in Nematodes

This review provides an overview of two complementary approaches to identify biologically active compounds for studies in chemical ecology. The first is activity-guided fractionation and the second is metabolomics, particularly focusing on a new liquid chromatography–mass spectrometry-based method c...

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Veröffentlicht in:	Integrative and comparative biology 2015-09, Vol.55 (3), p.478-485
Hauptverfasser:	Edison, Arthur S., Clendinen, Chaevien S., Ajredini, Ramadan, Beecher, Chris, Ponce, Francesca V., Stupp, Gregory S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Products - metabolism Caenorhabditis elegans Caenorhabditis elegans - physiology Chemical ecology Chemical Fractionation - methods Chemicals that Organize Ecology: Towards a Greater Integration of Chemoreception, Neuroscience, Organismal Biology, and Chemical Ecology Chemotaxis Chromatography Chromatography, Liquid Fractionation Mass Spectrometry Metabolites Metabolomics - methods Nematoda Nematoda - physiology Nematodes
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Zusammenfassung:	This review provides an overview of two complementary approaches to identify biologically active compounds for studies in chemical ecology. The first is activity-guided fractionation and the second is metabolomics, particularly focusing on a new liquid chromatography–mass spectrometry-based method called isotopic ratio outlier analysis. To illustrate examples using these approaches, we review recent experiments using Caenorhabditis elegans and related free-living nematodes.
ISSN:	1540-7063 1557-7023
DOI:	10.1093/icb/icv077