Hodgkin Lymphoma of the Nasopharynx: Case Report with Review of the Literature

Hodgkin Lymphoma of the Nasopharynx: Case Report with Review of the Literature

We report an uncommon case and histopathologic work-up of Hodgkin lymphoma of the nasopharynx in a 49-year old female patient who presented with a 2-year complaint of bilateral nasal congestion. Histologic study revealed a lymphocyte rich subtype of classic Hodgkin lymphoma. Immunohistochemical anal...

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Veröffentlicht in:Head & neck pathology (Totowa, N.J.) N.J.), 2015-09, Vol.9 (3), p.369-375
Hauptverfasser: Owosho, Adepitan A., Gooden, Casey E., McBee, Alden G.
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers, Tumor - analysis
Dentistry
Female
Hodgkin Disease - pathology
Humans
Immunohistochemistry
Medicine
Medicine & Public Health
Middle Aged
Nasopharyngeal Neoplasms - pathology
Oral and Maxillofacial Surgery
Original Paper
Otorhinolaryngology
Pathology
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Beschreibung
Zusammenfassung:We report an uncommon case and histopathologic work-up of Hodgkin lymphoma of the nasopharynx in a 49-year old female patient who presented with a 2-year complaint of bilateral nasal congestion. Histologic study revealed a lymphocyte rich subtype of classic Hodgkin lymphoma. Immunohistochemical analysis revealed CD15, CD30, OCT-2, BOB.1, and MUM-1 expression by the neoplastic cells and a lack of expression of CD45, CD20, CD3, EMA, and EBER. The review of the literature showed that Hodgkin lymphoma of the nasopharynx is rare, the most common reported subtype is the mixed cellularity, and Hodgkin lymphoma of the nasopharynx has a favorable prognosis.
ISSN:1936-055X
1936-0568
DOI:10.1007/s12105-015-0611-7