Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer
Highlights • Gd(DOTA) is stably conjugated to mesoporous silicon nanoconstructs for MR imaging. • Gd3+ -ions relaxivity is enhanced by 5 times as compared to clinical agents. • Nanoconstructs accumulate up to 2% ID/g tissue in low perfused ovarian tumors.
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| Veröffentlicht in: | Cancer letters 2014-09, Vol.352 (1), p.97-101 |
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| container_title | Cancer letters |
| container_volume | 352 |
| creator | Gizzatov, Ayrat Stigliano, Cinzia Ananta, Jeyerama S Sethi, Richa Xu, Rong Guven, Adem Ramirez, Maricela Shen, Haifa Sood, Anil Ferrari, Mauro Wilson, Lon J Liu, Xuewu Decuzzi, Paolo |
| description | Highlights • Gd(DOTA) is stably conjugated to mesoporous silicon nanoconstructs for MR imaging. • Gd3+ -ions relaxivity is enhanced by 5 times as compared to clinical agents. • Nanoconstructs accumulate up to 2% ID/g tissue in low perfused ovarian tumors. |
| doi_str_mv | 10.1016/j.canlet.2014.06.001 |
| format | Article |
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| ispartof | Cancer letters, 2014-09, Vol.352 (1), p.97-101 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Atoms & subatomic particles Breast cancer Contrast agents Contrast Media - chemistry Cytotoxicity Etching Hematology, Oncology and Palliative Medicine Heterocyclic Compounds - chemistry Humans Lymphatic system Magnetic Resonance Imaging Melanoma Mesoporous silicon Molecular Structure Nanoconstructs Nanoparticles Nanoparticles - chemistry Neoplasms - diagnosis NMR Nuclear magnetic resonance Organometallic Compounds - chemistry Ovarian cancer Pore size Porosity Relaxivity Silicon - chemistry Silicon wafers Tumors |
| title | Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer |
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