Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer

Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer

Highlights • Gd(DOTA) is stably conjugated to mesoporous silicon nanoconstructs for MR imaging. • Gd3+ -ions relaxivity is enhanced by 5 times as compared to clinical agents. • Nanoconstructs accumulate up to 2% ID/g tissue in low perfused ovarian tumors.

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Veröffentlicht in:Cancer letters 2014-09, Vol.352 (1), p.97-101
Hauptverfasser: Gizzatov, Ayrat, Stigliano, Cinzia, Ananta, Jeyerama S, Sethi, Richa, Xu, Rong, Guven, Adem, Ramirez, Maricela, Shen, Haifa, Sood, Anil, Ferrari, Mauro, Wilson, Lon J, Liu, Xuewu, Decuzzi, Paolo
Format: Artikel
Sprache:eng
Schlagworte:
Atoms & subatomic particles
Breast cancer
Contrast agents
Contrast Media - chemistry
Cytotoxicity
Etching
Hematology, Oncology and Palliative Medicine
Heterocyclic Compounds - chemistry
Humans
Lymphatic system
Magnetic Resonance Imaging
Melanoma
Mesoporous silicon
Molecular Structure
Nanoconstructs
Nanoparticles
Nanoparticles - chemistry
Neoplasms - diagnosis
NMR
Nuclear magnetic resonance
Organometallic Compounds - chemistry
Ovarian cancer
Pore size
Porosity
Relaxivity
Silicon - chemistry
Silicon wafers
Tumors
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Zusammenfassung:Highlights • Gd(DOTA) is stably conjugated to mesoporous silicon nanoconstructs for MR imaging. • Gd3+ -ions relaxivity is enhanced by 5 times as compared to clinical agents. • Nanoconstructs accumulate up to 2% ID/g tissue in low perfused ovarian tumors.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.06.001