Low-Dose Intravenous Soybean Oil Emulsion for Prevention of Cholestasis in Preterm Neonates

Background: Premature infants depend on intravenous fat emulsions to supply essential fatty acids and calories. The dose of soybean-based intravenous fat emulsions (S-IFE) has been associated with parenteral nutrition (PN)–associated liver disease. This study’s purpose was to determine if low-dose S-IFE is a safe and effective preventive strategy for cholestasis in preterm neonates. Materials and Methods: This is a multicenter randomized controlled trial in infants with a gestational age (GA) ≤29 weeks. Patients .2 for all). Conclusion: Compared with the control dose, low-dose S-IFE was not associated with a reduction in cholestasis or growth.