Activation of the insulin-signaling pathway in sciatic nerve and hippocampus of type 1 diabetic rats

Highlights • In insulin-deficient diabetes, the CNS is susceptible to the same changes as the PNS. • Ex vivo insulin triggers an enhanced activation of the insulin receptor in both the PNS and CNS from diabetic rats. • Low-dose insulin therapy in diabetic rats is sufficient to restore impaired insul...

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Veröffentlicht in:	Neuroscience 2015-09, Vol.303, p.220-228
Hauptverfasser:	King, M.R, Anderson, N.J, Liu, C, Law, E, Cundiff, M, Mixcoatl-Zecuatl, T.M, Jolivalt, C.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals diabetes Diabetes Mellitus, Type 1 - metabolism Disease Models, Animal Female Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta GSK3 hippocampus Hippocampus - drug effects Hippocampus - metabolism insulin Insulin - administration & dosage Insulin - metabolism insulin receptor Neurology Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Receptor, Insulin - metabolism sciatic nerve Sciatic Nerve - drug effects Sciatic Nerve - metabolism Signal Transduction
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Zusammenfassung:	Highlights • In insulin-deficient diabetes, the CNS is susceptible to the same changes as the PNS. • Ex vivo insulin triggers an enhanced activation of the insulin receptor in both the PNS and CNS from diabetic rats. • Low-dose insulin therapy in diabetic rats is sufficient to restore impaired insulin signaling to normal level and function.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.06.060