Attenuation of microglial RANTES by NEMO-binding domain peptide inhibits the infiltration of CD8+ T cells in the nigra of hemiparkinsonian monkey

Highlights • Marked presence of RANTES in the serum of hemiparkinsonian monkeys. • RANTES was centrally upregulated in the nigra of hemiparkinsonian monkeys. • Parkinsonian toxin MPP+ induced RANTES in microglial cells via NF-κB. • NBD peptide decreased RANTES and attenuated infiltration of CD8+ T c...

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Veröffentlicht in:	Neuroscience 2015-08, Vol.302, p.36-46
Hauptverfasser:	Roy, A, Mondal, S, Kordower, J.H, Pahan, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism CCAAT-Binding Factor - metabolism CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - physiology Cells, Cultured Chemokine CCL11 - metabolism Chemokine CCL5 - metabolism Cytokines - metabolism Disease Models, Animal DNA-Binding Proteins - metabolism Female Gene Expression Regulation - drug effects hemiparkinsonian monkeys Macaca mulatta Mice microglia Microglia - drug effects neuroinflammation Neurology Parkinsonian Disorders - pathology Parkinson’s disease Peptides - metabolism Peptides - pharmacology RANTES Substantia Nigra - pathology T cell infiltration Tyrosine 3-Monooxygenase - metabolism Up-Regulation - drug effects
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Zusammenfassung:	Highlights • Marked presence of RANTES in the serum of hemiparkinsonian monkeys. • RANTES was centrally upregulated in the nigra of hemiparkinsonian monkeys. • Parkinsonian toxin MPP+ induced RANTES in microglial cells via NF-κB. • NBD peptide decreased RANTES and attenuated infiltration of CD8+ T cells in nigra.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.03.011