Prenatal diagnosis of X‐linked adrenoleukodystrophy associated with isolated pericardial effusion

Key Clinical Message This is the first reported case of fetal pericardial effusion in association with X‐linked adrenoleukodystrophy and hypocortisolism from a nonautoimmune cause. Our hypothesis is that in experienced hands and after accurate genetic counseling, isolated pericardial effusion can constitute an indication for a severe metabolic disease. This is the first reported case of fetal pericardial effusion in association with X‐linked adrenoleukodystrophy and hypocortisolism from a nonautoimmune cause. Our hypothesis is that in experienced hands and after accurate genetic counseling, isolated pericardial effusion can constitute an indication for a severe metabolic disease.