Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014

[...]J. Wang et al. review epidemiological studies or controlled clinical trials which employed biomarkers of exposure for polyphenols to help assess their anticarcinogenic role and concluded that more evidences should be collected before a conclusion can be made towards their protective roles. A. Masci et al. showed that a raw broccoli sprout juice protects neuroblastoma cells against Aβ-induced cytotoxicity via the induction of antiapoptotic signals, such as increased Hsp70 mRNA levels, and the activation of Nrf2-ARE signalling pathway upregulation of Nrf2-dependent antioxidant capacity. Besides neurodegenerative disease and ageing, there are other disorders related to brain damage such as psychiatric disorders including major depression, attention deficit hyperactivity disease (ADHD) and schizophrenia, and cognitive deficit and brain damage induced by chronic alcohol consumption.