Genome-wide whole blood microRNAome and transcriptome analyses reveal miRNA-mRNA regulated host response to foodborne pathogen Salmonella infection in swine

To understand the role of miRNAs in regulating genes involved in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling of miRNAs and mRNAs from the whole blood of pigs upon Salmonella challenge was performed. A total of 62 miRNAs were differentially express...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5 (1), p.12620-12620, Article 12620
Hauptverfasser:	Bao, Hua, Kommadath, Arun, Liang, Guanxiang, Sun, Xu, Arantes, Adriano S., Tuggle, Christopher K., Bearson, Shawn M.D., Plastow, Graham S., Stothard, Paul, Guan, Le Luo
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 38/91 45/41 631/553 631/553/2711 Animals Bacterial diseases Blood Cation Transport Proteins - genetics Foodborne Diseases - microbiology Foodborne pathogens Gene expression Gene Expression Profiling Gene Expression Regulation Genome-Wide Association Study Genomes Host-Pathogen Interactions - genetics Humanities and Social Sciences Immune response Infections MicroRNAs - blood MicroRNAs - genetics miRNA multidisciplinary Pathogens Reproducibility of Results RNA, Messenger - blood Salmonella Salmonella Infections, Animal - genetics Salmonella Infections, Animal - immunology Science Sus scrofa - genetics Sus scrofa - microbiology
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Zusammenfassung:	To understand the role of miRNAs in regulating genes involved in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling of miRNAs and mRNAs from the whole blood of pigs upon Salmonella challenge was performed. A total of 62 miRNAs were differentially expressed post infection (false discovery rate
ISSN:	2045-2322 2045-2322
DOI:	10.1038/srep12620