An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes
Richard Gilbertson and colleagues report an in vivo screen of 84 candidate oncogenes and 39 candidate tumor-suppressor genes in ependymoma mouse models. The validated targets are involved in vesicle trafficking, DNA modification and cholesterol biosynthesis. Cancers are characterized by non-random c...
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Veröffentlicht in: | Nature genetics 2015-08, Vol.47 (8), p.878-887 |
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Sprache: | eng |
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Zusammenfassung: | Richard Gilbertson and colleagues report an
in vivo
screen of 84 candidate oncogenes and 39 candidate tumor-suppressor genes in ependymoma mouse models. The validated targets are involved in vesicle trafficking, DNA modification and cholesterol biosynthesis.
Cancers are characterized by non-random chromosome copy number alterations that presumably contain oncogenes and tumor-suppressor genes (TSGs). The affected loci are often large, making it difficult to pinpoint which genes are driving the cancer. Here we report a cross-species
in vivo
screen of 84 candidate oncogenes and 39 candidate TSGs, located within 28 recurrent chromosomal alterations in ependymoma. Through a series of mouse models, we validate eight new ependymoma oncogenes and ten new ependymoma TSGs that converge on a small number of cell functions, including vesicle trafficking, DNA modification and cholesterol biosynthesis, identifying these as potential new therapeutic targets. |
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ISSN: | 1061-4036 1546-1718 |
DOI: | 10.1038/ng.3323 |