Androgen metabolites impact CSF amines and axonal serotonin via MAO-A and -B in male macaques

Highlights • MAO-A expression was suppressed by metabolism of T to E. • MAO-B expression was increased by T and DHT. • Aromatase was not regulated by T or its metabolites. • CSF-5HIAA positively correlated with MAO-A expression.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-08, Vol.301, p.576-589
Hauptverfasser:	Bethea, C.L, Phu, K, Kim, A, Reddy, A.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - cerebrospinal fluid Analysis of Variance Androgen Antagonists - pharmacology Androgens - metabolism Androgens - pharmacology Androstatrienes - pharmacology Animals aromatase Aromatase - metabolism Aromatase Inhibitors - pharmacology Axons - metabolism CSF 5HIAA Dihydrotestosterone - pharmacology Flutamide - pharmacology Macaca Macaca fascicularis Macaca fuscata Male MAO-A MAO-B Monoamine Oxidase - genetics Monoamine Oxidase - metabolism Neurology Raphe Nuclei - metabolism RNA, Messenger - metabolism serotonin Serotonin - metabolism Testosterone - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • MAO-A expression was suppressed by metabolism of T to E. • MAO-B expression was increased by T and DHT. • Aromatase was not regulated by T or its metabolites. • CSF-5HIAA positively correlated with MAO-A expression.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.06.020