The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research

The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research

Clinical trials are the final links in the chains of knowledge and for determining the roles of therapeutic advances. Unfortunately, in an important sense they are the weakest links. This article describes two designs that are being explored today: platform trials and basket trials. Both are attempt...

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Veröffentlicht in:Molecular oncology 2015-05, Vol.9 (5), p.951-959
1. Verfasser: Berry, Donald A.
Format: Artikel
Sprache:eng
Schlagworte:
Basket trials
Bayesian adaptive clinical trials
Biology
Biomarker-driven clinical trials
Biomarkers
Biomarkers, Tumor - metabolism
Borrowing
Cancer research
Clinical medicine
Clinical trials
Design
Disease
Humans
Hypotheses
Hypothesis testing
Lung cancer
Medical research
Neoplasms - metabolism
Neoplasms - therapy
Patients
Platform trials
Review
Reviews
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Beschreibung
Zusammenfassung:Clinical trials are the final links in the chains of knowledge and for determining the roles of therapeutic advances. Unfortunately, in an important sense they are the weakest links. This article describes two designs that are being explored today: platform trials and basket trials. Both are attempting to merge clinical research and clinical practice.
ISSN:1574-7891
1878-0261
DOI:10.1016/j.molonc.2015.02.011