Single-molecule insights into mRNA dynamics in neurons

Highlights • mRNA localization into neuronal processes and localized translation is an efficient mechanism of local protein delivery in neurons due to their long processes and synaptic function. • Single-mRNA studies in neurons illustrate the diverse and stochastic nature of mRNA trafficking into ne...

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Veröffentlicht in:	Trends in cell biology 2015-08, Vol.25 (8), p.468-475
Hauptverfasser:	Buxbaum, Adina R, Yoon, Young J, Singer, Robert H, Park, Hye Yoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans In Situ Hybridization, Fluorescence - methods Intracellular Membranes - physiology local translation mRNA tracking Neuronal Plasticity - physiology Neurons - physiology Pathology Protein Biosynthesis - physiology RNA localization RNA, Messenger - physiology Signal Transduction - physiology smFISH
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Beschreibung
Zusammenfassung:	Highlights • mRNA localization into neuronal processes and localized translation is an efficient mechanism of local protein delivery in neurons due to their long processes and synaptic function. • Single-mRNA studies in neurons illustrate the diverse and stochastic nature of mRNA trafficking into neuronal processes. • Single-molecule imaging of endogenous mRNA has illuminated a novel and unexpected understanding of mRNA dynamics.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2015.05.005