Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death

Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause aging-related degenerative pathologies and increase cancer risk. However, a direct connection between oxidative damage to telomeric...

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Veröffentlicht in:	Nucleic acids research 2015-07, Vol.43 (13), p.6334-6347
Hauptverfasser:	Sun, Luxi, Tan, Rong, Xu, Jianquan, LaFace, Justin, Gao, Ying, Xiao, Yanchun, Attar, Myriam, Neumann, Carola, Li, Guo-Min, Su, Bing, Liu, Yang, Nakajima, Satoshi, Levine, Arthur S, Lan, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Death Cell Line Cellular Senescence DNA Damage DNA Repair Genome Integrity, Repair and Green Fluorescent Proteins - genetics Guanine - analogs & derivatives Guanine - metabolism Humans Oxidative Stress Repetitive Sequences, Nucleic Acid Telomere - chemistry Telomere - metabolism Telomere Shortening Telomeric Repeat Binding Protein 1 - genetics
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Beschreibung
Zusammenfassung:	Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause aging-related degenerative pathologies and increase cancer risk. However, a direct connection between oxidative damage to telomeric DNA, comprising
ISSN:	0305-1048 1362-4962
DOI:	10.1093/nar/gkv598