Pilot study on the bioactivity of vitamin d in the skin after oral supplementation

Laboratory studies suggest that vitamin D (VD) supplementation inhibits skin carcinogenesis. However, epidemiologic studies report mixed findings in the association between circulating VD levels and skin cancer risk. We conducted a clinical study to determine whether oral cholecalciferol supplementa...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2015-06, Vol.8 (6), p.563-569
Hauptverfasser:	Curiel-Lewandrowski, Clara, Tang, Jean Y, Einspahr, Janine G, Bermudez, Yira, Hsu, Chiu Hsieh, Rezaee, Melika, Lee, Alex H, Tangrea, Joseph, Parnes, Howard L, Alberts, David S, Chow, H-H Sherry
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Dietary Supplements Female Follow-Up Studies Humans Male Middle Aged Pilot Projects Receptors, Calcitriol - metabolism Skin - drug effects Skin - metabolism Skin - pathology Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - metabolism Vitamin D Deficiency - prevention & control
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Zusammenfassung:	Laboratory studies suggest that vitamin D (VD) supplementation inhibits skin carcinogenesis. However, epidemiologic studies report mixed findings in the association between circulating VD levels and skin cancer risk. We conducted a clinical study to determine whether oral cholecalciferol supplementation would exert direct bioactivity in human skin through modulation of the VD receptor (VDR). We enrolled 25 individuals with serum 25-hydroxyvitamin-D levels
ISSN:	1940-6207 1940-6215 1940-6215
DOI:	10.1158/1940-6207.CAPR-14-0280