Assessing contributions of nucleus accumbens shell subregions to reward-seeking behavior
Highlights • We explored functional heterogeneity across nucleus accumbens shell subregions. • Rats were trained to self-administer cocaine and subsequently extinguished. • Amphetamine microinfusions were targeted to subregions as reinstatement tests. • Targeting the dorsomedial shell led to signifi...
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| Veröffentlicht in: | Drug and alcohol dependence 2015-08, Vol.153, p.369-373 |
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| container_title | Drug and alcohol dependence |
| container_volume | 153 |
| creator | Reed, Michael D Hildebrand, David G.C Santangelo, Gabrielle Moffa, Anthony Pira, Ashley S Rycyna, Lisa Radic, Mia Price, Katherine Archbold, Jonathan McConnell, Kristi Girard, Lauren Morin, Kristen Tang, Anna Febo, Marcelo Stellar, James R |
| description | Highlights • We explored functional heterogeneity across nucleus accumbens shell subregions. • Rats were trained to self-administer cocaine and subsequently extinguished. • Amphetamine microinfusions were targeted to subregions as reinstatement tests. • Targeting the dorsomedial shell led to significant reinstatement. • No significant reinstatement was observed when targeting the intermediate zone. |
| doi_str_mv | 10.1016/j.drugalcdep.2015.05.001 |
| format | Article |
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| ispartof | Drug and alcohol dependence, 2015-08, Vol.153, p.369-373 |
| issn | 0376-8716 1879-0046 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amphetamine - administration & dosage Amphetamine - pharmacology Animals Cocaine - administration & dosage Conditioning, Operant - drug effects Conditioning, Operant - physiology Extinction, Psychological - drug effects Extinction, Psychological - physiology Male Microinjections Nucleus Accumbens - anatomy & histology Nucleus Accumbens - physiology Psychiatry Rats Rats, Sprague-Dawley Reward Self Administration |
| title | Assessing contributions of nucleus accumbens shell subregions to reward-seeking behavior |
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